The spatial position of a cell relative to neighboring cells and nearby non-cellular structures provides important clues about its phenotype, state, and function within native tissue.

Analyzing cells within their tissue environment is critical for understanding cell biology and disease pathology. It is increasingly clear that subcellular localization of messenger RNA (mRNA) varies depending on gene function, playing a key role in determining where proteins are synthesized and how they are transported within the cell.

Achieving high-throughput, high-resolution analysis of intracellular post-transcriptional targets across large tissue samples has long been a major challenge. With our innovative SpectrumFISH platform, we can perform large-scale, subcellular-resolution analysis of post-transcriptional regulation in fresh tissue samples spanning several centimeters—without the need for sequencing.